Neurologist, Pediatric Immunohematology Unit and Department of Neurology, San Raffaele Hospital, Milan (Italy)
Dr Fumagalli started her clinical and scientific career as an MD student in the Department of Neurology of San Raffaele Hospital, where she obtained her specialization in Neurology in 2009.
Since 2003 she acquired experience in adult general neurology and showing since the beginning a particular interest in inherited neurodegenerative collaborating with the outpatient service for Rare Neurological Disorders and San Raffaele Telethon Institute for Gene Therapy (SR-TIGET).
In 2004, she graduated from Vita-Salute San Raffaele University of Milan with a thesis entitled "Molecular, Neurophysiological and MRI study for the definition of nervous system damage caused by MLD. Prognostic and therapeutic implications” (final grade 110/110 with honours) under the supervision of Prof. G. Comi.
During the specialization, she continued her work on the natural history of MLD taking care of affected patients and studying instrumental prognostic biomarkers for MLD and quantitative tools for monitoring disease progression and evaluating the efficacy of innovative therapies.
She dedicated her PhD training in Paediatric Neurology at the Paediatric Unit of San Raffaele Hospital and collaborating to the phase I/II HSC Gene Therapy trial for MLD since 2010. Her responsibility was monitoring neurological outcomes of patients enrolled in the clinical trial and resulted in the PhD thesis: “Preliminary demonstration of the efficacy of lentiviral hematopoietic stem cell gene therapy in metachromatic leukodystrophy: analysis of neurological end-points”.
Between 2004 and 2013, she also learned skills in the field of Epilepsy as a resident at the Neurophysiology Service of the Regional Centre for Epilepsy of San Raffaele Hospital (reading EEG recording and working at the outpatient service for Childhood Epilepsy). Since 2010, she worked as a Consultant Neurologist at the San Raffaele Hospital Emergency department. Since 2013, she became a Consultant Neurologist and then a Staff Neurologist of the Department of Neurology and Paediatric Immunohematology Unit of San Raffaele Hospital in Milan, working as an investigator of the clinical trials on MLD and a consultant Paediatric Neurologist of the Paediatric Unit. Moreover, she collaborates with other Gene Therapy projects ongoing at SR-TIGET taking care of neurological aspects of other paediatric disorders (in particular ADA-SCID and MPS-I). Starting from February 2020, she acted as an ad hoc consultant of Orchard Therapeutics Advisory Boards.